Evolution of nitric oxide regulation of gut function
نویسندگان
چکیده
منابع مشابه
Nitric oxide synthases: regulation and function.
Nitric oxide (NO), the smallest signalling molecule known, is produced by three isoforms of NO synthase (NOS; EC 1.14.13.39). They all utilize l-arginine and molecular oxygen as substrates and require the cofactors reduced nicotinamide-adenine-dinucleotide phosphate (NADPH), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN), and (6R-)5,6,7,8-tetrahydrobiopterin (BH(4)). All NOS bin...
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15 صفحه اولNegative feedback regulation of endothelial cell function by nitric oxide.
The objective of this study was to determine whether nitric oxide (NO) could function as a negative feedback modulator of endothelial cell function by inhibiting NO synthase in vascular endothelial cells. The rationale for this approach was a previous study from this laboratory, which revealed that NO inhibits neuronal NO synthase from rat cerebellum. In the present study, NO and NO-donor agent...
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Nitric oxide (NO) produces rapid osteoclast detachment and contraction in vitro, and this effect is accompanied by a profound inhibition of bone resorption. Work by others has confirmed these findings in vivo: inhibition of NO synthase [NOS; L-arginine, NADPH: oxygen oxidoreductase (NO-forming), EC 1.14.13.39] in normal rats is followed by increased bone resorption reflected by a marked loss in...
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THIS SERIES OF SIX PAPERS covers the presentations from the Experimental Biology 2003 Symposium entitled “The Function and Regulation of Mitochondrially Produced Nitric Oxide in Cardiomyocytes,” sponsored by the American Physiological Society. Broadly, the topics include views on nitric oxide (NO) biochemistry in the mitochondrion and mitochondria-rich tissues, whether this NO has been endogeno...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2019
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1816973116